Brominated Sesquiterpenes from the Red Alga Laurencia obtusa
Identifieur interne : 002045 ( Main/Exploration ); précédent : 002044; suivant : 002046Brominated Sesquiterpenes from the Red Alga Laurencia obtusa
Auteurs : Gulaçt Topcu [États-Unis, Oman] ; Zeynep Aydogmus [États-Unis] ; Sedat Imre [États-Unis] ; Ahmet C. Gören [États-Unis] ; John M. Pezzuto [États-Unis] ; Jason A. Clement [États-Unis] ; David G. I. Kingston [États-Unis]Source :
- Journal of Natural Products [ 0163-3864 ] ; 2003.
Abstract
Four new sesquiterpenes, (8R*)-8-bromo-10-epi-β-snyderol (1), (8S*)-8-bromo-β-snyderol (2), 5-bromo-3-(3‘-hydroxy-3‘-methylpent-4‘-enylidene)-2,4,4-trimethylcyclohexanone (3), and the epoxide 4, have been isolated from the chloroform−methanol extract of Laurencia obtusa, together with the three known compounds α-snyderol (5), α-snyderol acetate (6), and stigmasterol. The structures of the isolated compounds were elucidated through spectroscopic analyses. Compound 1 showed antimalarial activity, with IC50 values of 2700 and 4000 ng/mL against the D6 and W2 clones of Plasmodium falciparum, respectively.
Url:
DOI: 10.1021/np030176p
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001143
- to stream Istex, to step Curation: 001143
- to stream Istex, to step Checkpoint: 000E80
- to stream Main, to step Merge: 002063
- to stream Main, to step Curation: 002045
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Brominated Sesquiterpenes from the Red Alga Laurencia obtusa</title><author><name sortKey="Topcu, Gulact" sort="Topcu, Gulact" uniqKey="Topcu G" first="Gulaçt" last="Topcu">Gulaçt Topcu</name></author><author><name sortKey="Aydogmus, Zeynep" sort="Aydogmus, Zeynep" uniqKey="Aydogmus Z" first="Zeynep" last="Aydogmus">Zeynep Aydogmus</name></author><author><name sortKey="Imre, Sedat" sort="Imre, Sedat" uniqKey="Imre S" first="Sedat" last="Imre">Sedat Imre</name></author><author><name sortKey="Goren, Ahmet C" sort="Goren, Ahmet C" uniqKey="Goren A" first="Ahmet C." last="Gören">Ahmet C. Gören</name></author><author><name sortKey="Pezzuto, John M" sort="Pezzuto, John M" uniqKey="Pezzuto J" first="John M." last="Pezzuto">John M. Pezzuto</name></author><author><name sortKey="Clement, Jason A" sort="Clement, Jason A" uniqKey="Clement J" first="Jason A." last="Clement">Jason A. Clement</name></author><author><name sortKey="Kingston, David G I" sort="Kingston, David G I" uniqKey="Kingston D" first="David G. I." last="Kingston">David G. I. Kingston</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:83429D45EC7A7844EA7E7B620A702CFFA8A410A0</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1021/np030176p</idno><idno type="url">https://api.istex.fr/ark:/67375/TPS-VN8FPXJS-L/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001143</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001143</idno><idno type="wicri:Area/Istex/Curation">001143</idno><idno type="wicri:Area/Istex/Checkpoint">000E80</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000E80</idno><idno type="wicri:doubleKey">0163-3864:2003:Topcu G:brominated:sesquiterpenes:from</idno><idno type="wicri:Area/Main/Merge">002063</idno><idno type="wicri:Area/Main/Curation">002045</idno><idno type="wicri:Area/Main/Exploration">002045</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brominated Sesquiterpenes from the Red Alga <hi rend="italic">Laurencia </hi><hi rend="italic">o</hi><hi rend="italic">btusa</hi></title><author><name sortKey="Topcu, Gulact" sort="Topcu, Gulact" uniqKey="Topcu G" first="Gulaçt" last="Topcu">Gulaçt Topcu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Oman</country></affiliation></author><author><name sortKey="Aydogmus, Zeynep" sort="Aydogmus, Zeynep" uniqKey="Aydogmus Z" first="Zeynep" last="Aydogmus">Zeynep Aydogmus</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Imre, Sedat" sort="Imre, Sedat" uniqKey="Imre S" first="Sedat" last="Imre">Sedat Imre</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Goren, Ahmet C" sort="Goren, Ahmet C" uniqKey="Goren A" first="Ahmet C." last="Gören">Ahmet C. Gören</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Pezzuto, John M" sort="Pezzuto, John M" uniqKey="Pezzuto J" first="John M." last="Pezzuto">John M. Pezzuto</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Clement, Jason A" sort="Clement, Jason A" uniqKey="Clement J" first="Jason A." last="Clement">Jason A. Clement</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Kingston, David G I" sort="Kingston, David G I" uniqKey="Kingston D" first="David G. I." last="Kingston">David G. I. Kingston</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey, TUBITAK, Marmara Research Center, Materialsand Chemical Technologies Research Institute, P.O. Box 21, 41470, Gebze-Kocaeli, Turkey, Department of Medicinal Chemistryand Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, and Department ofChemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Natural Products</title><title level="j" type="abbrev">J. Nat. Prod.</title><idno type="ISSN">0163-3864</idno><idno type="eISSN">1520-6025</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published" when="2003-10-24">2003</date><date when="2003-12-01">2003</date><biblScope unit="vol">66</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1505">1505</biblScope><biblScope unit="page" to="1508">1508</biblScope></imprint><idno type="ISSN">0163-3864</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0163-3864</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Four new sesquiterpenes, (8R*)-8-bromo-10-epi-β-snyderol (1), (8S*)-8-bromo-β-snyderol (2), 5-bromo-3-(3‘-hydroxy-3‘-methylpent-4‘-enylidene)-2,4,4-trimethylcyclohexanone (3), and the epoxide 4, have been isolated from the chloroform−methanol extract of Laurencia obtusa, together with the three known compounds α-snyderol (5), α-snyderol acetate (6), and stigmasterol. The structures of the isolated compounds were elucidated through spectroscopic analyses. Compound 1 showed antimalarial activity, with IC50 values of 2700 and 4000 ng/mL against the D6 and W2 clones of Plasmodium falciparum, respectively.</div></front></TEI><affiliations><list><country><li>Oman</li><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Virginie"><name sortKey="Topcu, Gulact" sort="Topcu, Gulact" uniqKey="Topcu G" first="Gulaçt" last="Topcu">Gulaçt Topcu</name></region><name sortKey="Aydogmus, Zeynep" sort="Aydogmus, Zeynep" uniqKey="Aydogmus Z" first="Zeynep" last="Aydogmus">Zeynep Aydogmus</name><name sortKey="Clement, Jason A" sort="Clement, Jason A" uniqKey="Clement J" first="Jason A." last="Clement">Jason A. Clement</name><name sortKey="Goren, Ahmet C" sort="Goren, Ahmet C" uniqKey="Goren A" first="Ahmet C." last="Gören">Ahmet C. Gören</name><name sortKey="Imre, Sedat" sort="Imre, Sedat" uniqKey="Imre S" first="Sedat" last="Imre">Sedat Imre</name><name sortKey="Kingston, David G I" sort="Kingston, David G I" uniqKey="Kingston D" first="David G. I." last="Kingston">David G. I. Kingston</name><name sortKey="Pezzuto, John M" sort="Pezzuto, John M" uniqKey="Pezzuto J" first="John M." last="Pezzuto">John M. Pezzuto</name></country><country name="Oman"><noRegion><name sortKey="Topcu, Gulact" sort="Topcu, Gulact" uniqKey="Topcu G" first="Gulaçt" last="Topcu">Gulaçt Topcu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002045 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002045 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:83429D45EC7A7844EA7E7B620A702CFFA8A410A0
|texte= Brominated Sesquiterpenes from the Red Alga Laurencia obtusa
}}
| This area was generated with Dilib version V0.6.33. |  |